Clinical Studies

Ongoing Studies

Study Name

Coordinator

Principal Investigator

Study Description and More Information

Study Name: Cochlear Nucleus 422 Electrode Expanded Criterion

Pamela Fiebig
312-695-8107

Alan Micco, MD

Study Description:

The objective of this study is to evaluate the safety and efficacy of the Cochlear Nucleus CI422 cochlear implant in adult subjects with expanded indications for candidacy. The primary efficacy endpoint will be subjects’ performance on an open set monosyllabic word recognition measure at the 6 month post-activation visit.

Study Name: Chronic Rhinosinusitis (CRS) Registry

CarolinePrice
312-695-0513

Bruce Tan, MD

Study Description:

The purpose of this registry is to collect clinical information on all consenting chronic rhinosinusitis (CRS) patients seen in the Otolaryngology Department. With this information, we will conduct studies to learn more about CRS and determine the most effective ways to treat this disease. The registry will also allow us to identify possible subjects for future studies.

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Study Name: Otonomy (Phase 2)

Sally Wroblewski
312 503 5389

Alan Micco, MD

Study Description:

This is a prospective, randomized, double-blind, placebo-controlled, multicenter, phase 3 study for patients with Meniere’s disease. The purpose of this study is to evaluate the effectiveness of OTO-104, a single intratympanic injection of a polaxemer gel with dexamethasone, for the treatment of Meniere's disease.

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Study Name:  Transoral Surgical Resection followed by Low-dose or Standard-dose IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer

Adam Prescott

312-926-2520

Caroline Price
312-695-0513

Bharat Mittal, MD

In collaboration with Northwestern Medicine’s Department of Radiation Oncology

Study Description:

This randomized phase II trial studies how well transoral surgery followed by low-dose or standard-dose radiation therapy works in treating patients with human papilloma virus (HPV) positive stage III-IVA oropharyngeal cancer. The purpose of this study is to study the effects, good and/or bad of performing surgery through the mouth (what is referred to as transoral surgery) followed by treatment that is selected based on studying the cancer under a microscope by a doctor (called a pathologist), on subjects and their human papillomavirus associated oropharynx cancer.

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Study Name: RESOLVE  II Steroid-Releasing S8 Sinus Implant

Sally Wroblewski
312 503 5389

Caroline Price
312-695-0513

Bruce Tan, MD

Study Description:

The goal of this study is to assess the safety and efficacy of the steroid-releasing S8 Sinus Implant in individuals who have had functional endoscopic sinus surgery in the past but still experience nasal and sinus obstruction.

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Study Name: Head Impulse Test (vHIT) for Meniere’s disease patients

Caroline Price
312-695-0513

Akihiro Matsuoka, MD

Study Description:

The objective of the study is to determine the clinical application of the video Head Impulse Test (vHIT) for Meniere’s disease patients. The vHIT is similar to a pair of goggles and uses infrared light (red light) and a camera to measure the movements of the eyes during these standard tests which may help to improve the understanding and diagnosis of Meniere’s disease.

Study Name: Aspirin Exacerbated Respiratory Disease (AERD) Study

Caroline Price
312-695-0513

Robert Schleimer, PhD

In collaboration with Northwestern University’s Allergy-Immunology Division

Study Description:

The purpose of this study is to evaluate the cause of Aspirin Exacerbated Respiratory Disease (AERD) also known as Samter’s Disease.

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Completed Studies

Study Name and Status

Coordinator

Principal Investigator

Study Description and More Information

Study Name: Improving the Symptom-Based Diagnosis of Chronic Sinusitis

Caroline Price
312-695-0513

Bruce Tan, MD

Study Description:

This study’s aim was to better diagnose chronic sinusitis by using a patient’s symptoms. We studied patterns of symptoms that will help us improve our ability to determine whether a patient has chronic sinusitis or another condition with similar symptoms such as nasal allergies or migraine headaches.

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Study Name: Patient Knowledge and Perception of Sinus CT Scans

Caroline Price
312-695-0513

Rakesh Chandra, MD

Study Description:

In this study, we studied patients’ knowledge and perceptions of in-office CT scans as well as their acceptance of CT scans as a necessary part of standard clinical care. We wanted to determine the factors that influence patients’ knowledge of CT scans and the most common concerns that patients have relating to using a CT scan to help diagnose their nasal or sinus condition.

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Study Name:RESOLVE - Steroid-Releasing S8 Sinus Implant

Sherrie Wolfe
312 503 2308

Caroline Price
312-695-0513

Rakesh Chandra, MD

Study Description:

The goal of this study was to assess the safety and efficacy of the steroid-releasing S8 Sinus Implant in individuals who have had functional endoscopic sinus surgery in the past but still experience nasal and sinus obstruction.

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Study Name: Steroid Therapy Before Surgery in Patients with Chronic Sinusitis with Nasal Polyps

Caroline Price
312-695-0513

Robert Schleimer, PhD

In collaboration with Northwestern University’s Allergy-Immunology Division

Study Description:

In this study, we studied which chronic sinusitis patients benefit from steroids before they have surgery. For some doctors, it is common practice to use these medications immediately prior to planned sinus surgery, to lessen inflammation and possibly to help the healing process. Other physicians feel oral steroids may not be helpful in this way and there is no conclusive data as to whether this practice has long term benefit.

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Study Name: Laryngopharyngeal Reflux (LPR) pH Probe

Caroline Price
312-695-0513

Bruce Tan, MD

Study Description:

In this study, we examined whether a device called a pH probe can help physicians predict if a patient will benefit from the current treatment for LPR, called proton pump inhibitor (PPI) medication. The pH probe was worn by participants in  for 24 hours and measured acidity levels before eating, sleeping, and laying down, to assess reflux measures as a baseline prior to starting PPI medication.

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Study Name: Short-Term Steroid Therapy in Patients with Chronic Sinusitis without Nasal Polyps

Caroline Price
312-695-0513

Bruce Tan, MD

Study Description:

In this study, we were interested in examining the most effective route to administer steroids to patients with chronic sinusitis (CRS). There is no conclusive data as to whether oral or sprayed nasal steroids are more effective in providing long-term benefit to patients. We compared patients compared patients treated with antibiotics and oral steroids to patients who receive antibiotics and nasally sprayed steroid therapy.

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Study Name: OptiNose

Julie Johnson
312-503-2338

Caroline Price
312-695-0513

Rakesh Chandra, MD

Study Description:

In this study, were interested in determining whether a new device that administers steroid medications in the nose would help improve symptoms of nasal congestion and obstruction in patients with bilateral nasal polyps.

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Study Name: MERLOT - Medical Therapy Versus Balloon Sinus Dilation for Patients with Chronic Rhinosinusitis

Julie Johnson
312-503-2338

Caroline Price
312-695-0513

Rakesh Chandra, MD

Study Description:

In this study, we compared health outcomes for patients with chronic rhinosinusitis (CRS) who are treated with continued medical therapy and those who are treated with balloon sinus dilation, a surgical procedure. Both of these options are considered routine medical care.

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Study Name: RESOLVE I – Steroid-Releasing S8 Sinus Implant Clinical Trial

Sherrie Wolfe
312 503 2308

Caroline Price
312-695-0513

Rakesh Chandra, MD

Study Description:

The goal of this study was to assess the safety and efficacy of the steroid-releasing S8 Sinus Implant in individuals who had functional endoscopic sinus surgery in the past but still experienced nasal and sinus obstruction.

Read more about this study